H2S donor

H2S Donor 5a is a H2S donor that could mimic the slow and continuous H(2)S generation process.

GYY4137 (GYY 4137 morpholine salt) is a novel water-soluble and slow releasing H2S donor with vasodilator and antihypertensive activity. GYY4137 also exhibits anti-inflammatory and anticancer activity.

Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sulfide (hydrate) is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration, reduces airway inflammation, and protects neurites, heart, and intestine from chemical or ischemic-reperfusion damage.

FW1256 is a phenyl analog. It also a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and causes cell apoptosis. FW1256 shows potent anti-inflammatory effects. It also has the potential for cancer and cardiovascular disease trea

JK-2 is a hydrogen sulfide (H2S) donor. At acidic pH, it shows a greatly accelerated H2S release upon protonation-induced intramolecular cyclization.

Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, Desmethylanethol trithione improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.

Diallyl Trisulfide is an organic polysulfide compound found in garlic that acts as an H2S donor.